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The pathology and natural course of borderline ovarian tumors (BOT) are different from those of invasive ovarian cancers. The aim of this study was to clarify the early detection of BOT in screening for ovarian cancer. During a 5-year period, 90,222 women were screened in our hospital. Serum CA-125 and transvaginal color Doppler sonography were performed at screening and after 6-month interval. The 3-year cumulative risks of first screening-detected BOT were 0.1%, 0.3%, 0.7%, 1.4%, 2.3%, and 1.2%, and those of second screening-detected BOT were 0.2%, 0.2%, 0.6%, 1.3%, 2.2%, and 1.4% at each age group. The risks of BOT detection were similar in women without and with family history. Multivariate analysis identified the combination of using CA-125 and Doppler method for first screening as being significant independent factor for BOT. In patients with BOT detected during the first screening, 19 (63%) of 30 had stage I disease, and 12 (41%) of the latter underwent interval screening. Screening for BOT at a younger age or using the combination of CA-125 and Doppler sonography may help in detecting asymptomatic early stage and thus
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The cytoskeletal reorganization was examined in rat synaptosomes to see whether oxidative stress could be involved in it. The reorganization consisted of two distinct events; the first one was a rapid shrinkage of the vesicles, and the second one was a subsequent extension of the pre-existing microtubules, which is considered as a possible molecular mechanism for synaptic vesicle recovery from inhibition of synaptic vesicle accumulation. In the vesicle shrinkage the involvement of free radical species was examined using xanthine oxidase, catalase and superoxide dismutase. It was observed that hydrogen peroxide induced the vesicle shrinkage, but superoxide dismutase prevented it, and the involvement of the intermediate products of xanthine oxidase, such as hypoxanthine and xanthine, was verified by the subsequent incubation of the synaptosomes in the presence of the respective
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